Cancer Cell (2027)

Cancer Cell advances a systemic understanding of cancer as a dynamic interplay between tumor cells, microenvironment, microbiota, nervous system, and host physiology. We bridge foundational discoveries and clinical innovation through bidirectional translation, integrating disciplines and transformative technologies—including AI, spatial multi-omics, single-cell sequencing, and functional genomics—to decode cancer's complexity.We prioritize studies unraveling tumor heterogeneity, immune evasion, metabolic reprogramming, and therapeutic resistance, emphasizing clinical trials with biological insights and preclinical work grounded in clinical hypotheses.